Blow-Fill-Seal Technology is considered as a superior form of aseptic processing in the packaging of pharmaceutical products. The underlying principle is that the container is formed, filled and sealed in a continuous process without human intervention in a sterile enclosed area inside a machine. This process not only allows greater freedom in package design, but it also reduces the risk of contamination and provides more economical alternative to conventional aseptic processing.
The process can be described as follows:
a.
Pharmaceutical grade Thermoplastic resin extrudes into a tubular shaped Parison.
b.
After reaching the desired height, the Parison is cut by closing the mold from the bottom. The top is then moved to an appropriate position where the blowing and filling nozzle is positioned.
c.
The Blow-Fill nozzle is inserted from the top and the container is formed by blowing sterile filtered compressed air and expanding it against the cooled walls. The sterile product from the fill nozzle is then filled into the newly formed container and the nozzle retracts back.
d.
The filled container is then hermetically sealed by the closing of separate sealing molds.
e.
The mold is then opened to deliver the formed, filled, sealed container out of the machine.
